NTP Research Concept: Artificial Butter Flavoring and Certain Components, Diacetyl and Acetoin

program prior to designing and conducting toxicology studies. The purpose of the research concept document is to outline the general elements of a research program that would address the specific public health concerns that prompted the nomination of the substance or issue for study. It may also encompass substance-specific studies that address larger public health issues or topics in toxicology. Additional information about the nomination, review, and selection of substances for study by the NTP is provided at Nominations to the NTP Testing Program (http://ntp.niehs.nih.gov/go/nom). A draft version of this research concept was reviewed by the NTP Board of Scientific Counselors at a public meeting on June 22, 2007 (http://ntp.niehs.nih.gov/go/9741), subsequently revised, and approved by the NTP Executive Committee.